The surplus rise in autoantibodies to the used antigens may induce embryotoxic effect, being one of the most common causes of miscarriage and pregnancy abnormalities. Harmful environmental factors, infectious diseases, or metabolic changes can affect the serum level of examined autoantibodies in vitro assay for evaluation of autoantibodies of IgG class in blood serum of women of reproductive age, steady abnormalities in production of which can be cause of infertility, habitual miscarriages or fetal malformations.