Any chronic diasease is based upon stable changes in production and transformation  of certain molecular components in some cellular popullations. such molecular changes may begin month or years before the first signs of clinical manifestation, and are accompanied by inevitable quantiiative  changes in antigenic content in some or many organs.

In vitro assay for the evalution of a panel of autoantibodies of IgG class, against antigens of the main human organs and system(nervous system, heart, liver, kidneys,lungs, stomach, intestinum, thyroid gland, pancreatic gland, adrenal gland, prostate gland, blood platelets, vessels endothelium, connective tissue ) , as well as to antigens characterizing the state of the immune system in the blood serum of examined patients.